First case of persistent Stenotrophomonas maltophilia bacteraemia due to septic thrombosis successfully treated with a cefiderocol-containing regimen

First case of persistent Stenotrophomonas maltophilia bacteraemia due to septic thrombosis successfully treated with a cefiderocol-containing regimen

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ABSTRACT: Introduction: There is Pegged Puzzles scarce evidence in literature of what should be the best antimicrobial treatment for bloodstream infections (BSIs) sustained by Stenotrophomonas maltophilia, a peculiar pathogen that intrinsically withstands to most of the available antibiotics.Results and conclusion: Here, we describe a challenging case of a persistent S.maltophilia BSI due to septic thrombosis successfully treated with the addition of the novel siderophore cephalosporin cefiderocol to an only partially effective levofloxacin regimen.

Additionally, an intra-lock therapy with trimethoprim/sulfamethoxazole was selected as 111 a strategy to prevent recurrence of infection since complete source control was not possible.The serum bactericidal assay was also used to corroborate the in vivo efficacy of the adopted combination therapy.